Have you ever been prescribed a drug only to find the cure is either worse than the disease, or can cause the disease? If you've taken Prilosec (just to name one), the answer is "yes."
A significant proportion of the world's population — and about 1 in every 20 Americans — are taking drugs that drastically reduce the level of stomach acid. They're called proton pump inhibitors, or PPIs.
"These drugs are actually creating the disorder that the drugs are used to treat," says Dr. Kenneth McColl of the University of Glasgow, who wrote an accompanying editorial on the study.
These drugs quench stomach acid almost like turning off a spigot. Taking PPIs typically reduces people's stomach acid to less than 10 percent of normal levels.
That's a good thing for millions who suffer from heartburn or GERD, gastroesophageal reflux disease. But a recent study found that when people stop taking these popular pills many experience painful "rebound" symptoms, often worse than before they started taking the drug. The healthy people in the study didn't have stomach problems to begin with, but they developed heartburn, acid reflux and indigestion when they stopped taking PPI pills after three months.
Molly Houston, a 66-year-old retired math and science teacher in Albequerque, N.M., knows how hard and painful it can be. Her doctor prescribed a common PPI called Prilosec (omeprazole) when she got heartburn from taking an antibiotic on top of arthritis drugs.
After a few weeks on the Prilosec, Houston stopped taking the pills. She doesn't like to be on any more drugs than she has to.
But four days after she stopped Prilosec she had severe stomach pain. "I had never had anything this bad. It was terrible," she says. "It was like somebody poured a quart of hydrochloric acid into my stomach."
To quell the burn, she immediately went back on Prilosec.
Houston had what researchers call "acid rebound." Stomach cells that make acid multiply over several weeks of exposure to a PPI in an effort to overcome the drug's effect. When the PPI is stopped, they pour out more acid than ever.
Treatment Can Make It Worse
Acid rebound is a well-known phenomenon. But many doctors thought it didn't really matter.
"I think everybody has held the belief that this had no significance at all," says Christina Reimer, a researcher at Copenhagen University in Denmark. She says many thought PPI acid rebound "was a merely physiological phenomenon that was not able to induce symptoms."
But Reimer and her colleagues showed that's not so. They recruited 120 healthy young adults without any stomach problems. Half went on a PPI drug for three months. The others got a placebo pill. Then researchers stopped all the pills and measured heartburn, acid reflux and indigestion in both groups.
"Forty-four percent, in the four weeks after discontinuation, developed one of these symptoms in the actively treated group compared to only 9 percent in the placebo group," Reimer says. "The difference was quite convincing."
The Copenhagen group found acid rebound can cause painful symptoms for weeks after the PPI drug is stopped. Their study is in the July issue of the journal Gastroenterology.....
you can find the rest of the article at NPR
I get Migraines, my mom really suffers from them. We compare notes on the different drugs we've been prescribed to stop the headaches. Years after prescribing her a common headache medication called Fiorinal (generically butalbital), my mom's doctor made a casual aside that taking the drug too long, or too frequently, could cause "breakthough headaches" that were as painful as the migraines they were supposed to treat. Hello? Do you think you could have mentioned that sooner? Like when Mom complained of 2-3 migraines per week? Or maybe when you were about to refill the prescription for the umpteenth time?
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Just because a drug is prescribed by a physician doesn't mean it's 100% safe. More importantly, as my son's pediatrician put it: "Any drug that claims it has no side effects is just snake oil. The question is really, are the side effects worth the benefits the drug provides?" In the case of Prilosec, and Fiorinal, my vote would be no.
And those statin drugs (Lipitor, et al) that are supposed to lower cholesterol levels? Once on them, you're on them for life. So it might be a good idea to ask a 20-something woman if she wants to have babies EVER, before prescribing a drug she's supposed to take for the rest of her life. Yeah, that's what the fast talking announcer in the TV ads is implying when he says "women who are pregnant or planning to become pregnant should not take <insert drug name here>." He means "planning to become pregnant sometime before menopause." That's more than a minor side effect.
How about this? Wouldn't it be great if insurance plans reimbursed doctors for appointments to discuss lifestyle changes with a patient? Isn't patient education and prevention worth covering? In the discussions about reducing healthcare costs, could someone please ask why insurers will cover costs for 20-40 years of prescription drug refills but not a couple of extended office visits? I'm just sayin...
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